Benadryl (Diphenhydramine) is an antihistamine commonly used in IV infusion therapy to provide relief from allergies, motion sickness, nausea, and vomiting. When administered intravenously, it works quickly to block histamine, the substance responsible for allergic reactions, and helps alleviate symptoms like itching, swelling, and hives. IV Benadryl is also useful for inducing sedation during medical procedures, helping patients relax or fall asleep when necessary. It’s commonly administered in outpatient and clinic settings when a fast, effective response is needed, especially for managing allergic reactions or providing mild sedation. While not typically used for emergencies like anaphylaxis, its quick onset in IV form makes it a valuable option for managing non-emergency allergic symptoms, nausea, and motion sickness.